PSU has two major campuses: the Manalo Campus, where the Laboratory Elementary School, Graduate School and School of Law are, and the Main Campus in Tiniguiban Heights, which houses the administration building, the colleges, the Laboratory High School, and the physical plant offices.
In addition, a number of extramural studies and programs are being offered in the Palawan State University's College of Community Resources and Development (CCRD) in rural campuses of Rizal, Narra, Quezon, Araceli, Brooke's Point, San Vicente, Cuyo, Coron, Balabac, Roxas, Taytay, El Nido, Linapacan, San Rafael, Sofronio Española, Dumaran and Bataraza.
Main Campus, Tiniguiban Heights, Puerto Princesa City: Established on June 19, 1965 (RA4303)
PSU Rizal Campus - Established: June 2000
PSU Narra Campus, Established: February 2002
PSU Quezon Campus, Established: May 1994
PSU Brooke's Point Campus, Established: June 1985
PSU Balabac Campus
PSU Sofronio Española Campus, Established: 2004
PSU North Campuses
PSU Araceli Campus, Established: August 1994
PSU Dumaran Campus, Established: June 2004
PSU Roxas Campus, Established: July 1984
PSU El Nido Campus, Established: July 1989
PSU Linapacan Campus
PSU Cuyo Campus